Introduction and Application

DMAE-NHS is used in chemiluminescence and immunoassay, receptor analysis, nucleic acid and peptide detection, etc. As a chemiluminescent agent for direct chemiluminescent immunoassay, it is used for the detection and analysis of antigens, antibodies, proteins, etc. No additional catalyst is required during the detection and analysis process. When DMAE-NHS is oxidized by H2O2 in an alkaline medium, it passes through a dioxyketone intermediate to produce electrically excited N-methylacridone, which releases photons at 430nm when it returns to the ground state.

Applications:

1. Used for infectious diseases, heart disease, and pregnancy testing;

2. Used for the detection of markers such as liver and gastric cancer;

3. Used for the diagnosis of hyperthyroidism, hypothyroidism, and autoimmune thyroid disease;

4. Used for the diagnosis and monitoring of diabetes and the detection of hypertension during pregnancy;

5. Used for the detection of various infectious diseases and heart diseases.

Advantages:

1. Compared with other acridinium salts, DMAE-NHS has higher luminescence efficiency;

2. DMAE-NHS has better thermal stability and stronger hydrophilicity;

3. DMAE-NHS has high photon yield and low background;

4. After coupling with proteins, antigens, antibodies, etc., the luminescence efficiency is almost unaffected, and it is an excellent chemiluminescent immunoassay labeling reagent.