What Is Tetrabutylammonium Hydrogen Sulfate?

Tetrabutylammonium Hydrogen Sulfate Cas 32503-27-8, abbreviated as TBAHS, is a quaternary ammonium salt with a molecular weight of 339.53. It is a white crystalline solid at room temperature with a melting point of 169–171°C. It is hygroscopic, soluble in water, and readily oxidised. When reacted with strong bases, it yields an equilibrium mixture containing a quaternary ammonium base. It is irritating to the eyes, skin, and respiratory tract and can cause severe skin burns and eye damage.

What Is Tetrabutylammonium Hydrogen Sulfate Made Of?

Tetrabutylammonium hydrogen sulfate is primarily prepared using two methods: First, by reacting iodobutane with tributylamine in acetonitrile, followed by refluxing the mixture with methyl hydrogen sulfate to synthesise the compound, the product is then purified by distillation. Second, using tetrabutylammonium hydrogen sulfate as the starting material, it is reacted with concentrated sulfuric acid in dichlorethane to replace bromide ions with hydrogen sulfate ions, and the product is obtained through crystallisation and drying. Tetrabutylammonium hydrogen sulfate is one of the most widely used phase-transfer catalysts, employed in the preparation of methylenedicarboxylate esters, the synthesis of ethers, indole N-alkylation, and the dehalogenation of halogenated hydrocarbons to produce alkyne hydrocarbons. In analytical chemistry, tetrabutylammonium hydrogen sulfate can serve as a mobile phase component in high-performance liquid chromatography (HPLC) for the separation of pharmaceuticals.

What Are the Properties of Tetrabutylammonium Hydrogen Sulfate?

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What is Tetrabutylammonium Hydrogen Sulfate Used For?

Tetrabutylammonium hydrogen sulfate can be used as a phase-transfer catalyst, surfactant, catalyst, emulsifier, disinfectant, bactericide, antistatic agent, and more. It is also used in reverse-phase high-performance liquid chromatography to determine oxalic acid in plant tissues and root exudates as a substance in aqueous solution systems.

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